Medications can interact with alcohol and other medicines - over-the counter, prescribed and illegal drugs
Centers for Disease Control and Prevention (CDC)
If you drink alcohol while using other drugs, the effects may be stronger and more deadly than using either one alone. To keep yourself safe and healthy, you should not drink alcohol when using other drugs. It can also be dangerous to use two or more drugs at the same time, or within a short time of each other.
Alcohol and other drug use includes drinking alcohol and taking other drugs, such as:
• Cannabis, also called marijuana, is often used to change mood and perceptions. Cannabis is illegal at the federal level and can have health risks regardless of how you use it. Some cannabis-based medicines are approved to help treat seizures and nausea in people with certain conditions.
• Opioids are commonly used to reduce pain. Health care providers or pharmacists might give patients oxycodone (OxyContin), hydrocodone (Vicodin), morphine, methadone, and fentanyl. Illicit opioids include heroin and illegally made fentanyl.
• Benzodiazepines are prescribed to help treat sleep problems, seizures, and mental health conditions like depression and anxiety.. Examples include diazepam (Valium), alprazolam (Xanax), zolpidem (Ambien), and eszopiclone (Lunesta).
• Stimulants, also called "uppers," increase your heart rate and blood pressure to dangerous levels. Some stimulants, like amphetamines, can be used to treat attention deficit hyperactivity disorder (ADHD). Examples of other stimulants include caffeine, methamphetamine, cocaine, and ecstasy.
• Psychedelics, or hallucinogens, change mood, thoughts, and perceptions for some time. This includes drugs like psilocybin (magic mushrooms), LSD, and ketamine.
Medicines, both over-the-counter (OTC) and prescribed
Drinking alcohol and taking certain medicines that are over-the-counter (OTC) or prescribed by a health care provider or pharmacist can cause harm. It could be dangerous if the medicine:
• Has a label saying there could be harmful effects when combined with alcohol.
• Is taken in a different way than prescribed.
• Was not given to you by your health care provider or pharmacist.
If you are taking medicine and considering drinking, talk to a health care provider or pharmacist first.
Health effects
Fact: Drinking alcohol at the same time, or within a few hours, of using other drugs like opioids or benzodiazepines can cause serious harm. It can make it difficult to breathe, which can damage your brain and other organs. This can also lead to early death. Using alcohol together with other drugs can increase your risk of:
• Overdose.
• Injury.
• Violence.
• Sex without protection, which can lead to sexually transmitted infections, HIV, or unplanned pregnancy.
• Chronic disease.
• Alcohol or other substance use disorders.
What can be done
You can avoid the harms that come from mixing alcohol and drugs. To keep yourself safe and healthy, you:
• Should NOT drink alcohol when using other drugs.
• Should AVOID misusing prescription drugs and using illicit drugs.